Chronic low back pain caused by intervertebral disc (IVD) degeneration, also termed chronic
discogenic low back pain (CD‐LBP), is one of the most prevalent musculoskeletal diseases …

Biomaterials for nucleus pulposus (NP) replacement and regeneration have great potential
to restore normal biomechanics in degenerated intervertebral discs following nucleotomy …

As one of the most common clinical disorders, low back pain (LBP) influences patient quality
of life and causes substantial social and economic burdens. Many factors can result in LBP …

Intervertebral disc degeneration (IDD)-induced low back pain significantly influences the
quality of life, placing a burden on public health systems worldwide. Currently available …

Porcine notochordal cell-derived matrix (NCM) has anti-inflammatory and regenerative
effects on degenerated intervertebral discs. For its clinical use, safety must be assured. The …

Despite the significant global prevalence of chronic pain, current methods to identify pain
therapeutics often fail translation to the clinic. Phenotypic screening platforms rely on …

Type I collagen is a predominant fibrous protein that makes up the extracellular matrix.
Collagen enhances cell attachment and is commonly used in three-dimensional culture …

Bioscaffolds derived from the extracellular matrix (ECM) have shown the capacity to promote
regeneration by providing tissue-specific biological instructive cues that can enhance cell …

Low back pain, knee osteoarthritis, and cancer patients suffer from chronic pain. Aberrant
nerve growth into intervertebral disc, knee, and tumors, are common pathologies that lead to …

The human spine consists of 26 vertebrae: seven cervical, 12 thoracic, five lumbar, five
sacral and four coccygeal vertebrae. Sacral and coccygeal vertebrae are fused together; the …