Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Cell migration through solid tissue often involves large contortions of the nucleus, but
biological significance is largely unclear. The nucleoskeletal protein lamin-A varies both …

It has been recognized that cancer is not merely a disease of tumor cells, but a disease of
imbalance, in which stromal cells and tumor microenvironment play crucial roles …

The identification of stem-cell-like cancer cells through conventional methods that depend
on stem cell markers is often unreliable. We developed a mechanical method for selecting …

Cell adhesion to the extracellular matrix has important roles in tissue integrity and human
health. Integrins are heterodimeric cell surface receptors that are composed by two non …

Fibronectin is a matrix glycoprotein which has not only been found to be over-expressed in
several cancers, but has been shown to participate in several steps of tumorigenesis. The …