Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy

AL Vijayan, null Vanimaya, S Ravindran… - Journal of intensive …, 2017 - Springer
Background Sepsis is a global healthcare problem, characterized by whole body
inflammation in response to microbial infection, which leads to organ dysfunction. It is …

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

RS Hotchkiss, G Monneret, D Payen - Nature Reviews Immunology, 2013 - nature.com
Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

Emerging technologies for molecular diagnosis of sepsis

M Sinha, J Jupe, H Mack, TP Coleman… - Clinical microbiology …, 2018 - Am Soc Microbiol
Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

Cardiorenal syndrome: an overview

C Ronco, A Bellasi, L Di Lullo - Advances in chronic kidney disease, 2018 - Elsevier
It is well established that a large number of patients with acute decompensated heart failure
present with various degrees of heart and kidney dysfunction usually primary disease of …

The clinical challenge of sepsis identification and monitoring

JL Vincent - PLoS medicine, 2016 - journals.plos.org
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Sepsis and septic shock: current approaches to management

K Thompson, B Venkatesh, S Finfer - Internal medicine journal, 2019 - Wiley Online Library
Sepsis, defined as life‐threatening organ dysfunction due to a dysregulated host response
to infection, is recognised by the World Health Organization as a global health priority. Each …

Bioanalytical chemistry of cytokines–a review

JA Stenken, AJ Poschenrieder - Analytica chimica acta, 2015 - Elsevier
Cytokines are bioactive proteins produced by many different cells of the immune system.
Due to their role in different inflammatory disease states and maintaining homeostasis, there …

Effect of sodium selenite administration and procalcitonin-guided therapy on mortality in patients with severe sepsis or septic shock: a randomized clinical trial

F Bloos, E Trips, A Nierhaus, J Briegel… - JAMA internal …, 2016 - jamanetwork.com
Importance High-dose intravenous administration of sodium selenite has been proposed to
improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided …

Graphene enabled low‐noise surface chemistry for multiplexed sepsis biomarker detection in whole blood

U Zupančič, P Jolly, P Estrela… - Advanced Functional …, 2021 - Wiley Online Library
Affinity‐based electrochemical (EC) sensors offer a potentially valuable approach for point‐
of‐care (POC) diagnostics applications, and for the detection of diseases, such as sepsis …

Biomarkers in sepsis

TSR Van Engelen, WJ Wiersinga… - Critical care …, 2018 - criticalcare.theclinics.com
Sepsis is characterized by complex pathophysiology and heterogeneous phenotypes of
affected patients regarding their symptoms, response to treatment, and outcomes. At present …