Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

J Zhu, B Guo, X Gan, L Zhang, Y He, B Liu, X Chen… - BMC Oral Health, 2017 - Springer
Background This study aimed to assess the difference in serum levels of leptin and
adiponectin in patients with periodontitis and in periodontally healthy individuals and …

Obesity and critical illness: insights from animal models

PN Mittwede, JS Clemmer, PF Bergin, L Xiang - Shock, 2016 - journals.lww.com
Critical illness is a major cause of morbidity and mortality around the world. While obesity is
often detrimental in the context of trauma, it is paradoxically associated with improved …

Pioglitazone reduces inflammation through inhibition of NF-κB in polymicrobial sepsis

J Kaplan, M Nowell, R Chima, B Zingarelli - Innate immunity, 2014 - journals.sagepub.com
The insulin sensitizing thiazolidinedione drugs, rosiglitazone and pioglitazone are specific
peroxisome proliferator-activated receptor-gamma agonists and reduce pro-inflammatory …

The surviving sepsis campaign: basic/translational science research priorities

CS Deutschman, J Hellman, RF Roca… - Intensive care medicine …, 2020 - Springer
Objectives Expound upon priorities for basic/translational science identified in a recent
paper by a group of experts assigned by the Society of Critical Care Medicine and the …

The impact of obesity on sepsis mortality: a retrospective review

EF Kuperman, JW Showalter, EB Lehman… - BMC infectious …, 2013 - Springer
Background Recent sepsis guidelines have focused on the early identification and risk
stratification of patients on presentation. Obesity is associated with alterations in multiple …

Dietary supplementation with nonfermentable fiber alters the gut microbiota and confers protection in murine models of sepsis

MJ Morowitz, V Di Caro, D Pang, J Cummings… - Critical care …, 2017 - journals.lww.com
Objectives: Links between microbial alterations and systemic inflammation have been
demonstrated in chronic disease, but little is known about these interactions during acute …

Metabolic pathways involved in formation of spontaneous and lipopolysaccharide-induced neutrophil extracellular traps (NETs) differ in obesity and systemic …

I Cichon, W Ortmann, E Kolaczkowska - International Journal of …, 2021 - mdpi.com
Obesity manifests itself with low-grade chronic inflammation that shapes immune responses
during infection. Albeit obese individuals are at risk of higher mortality due to comorbidities …

[HTML][HTML] Soluble dietary fiber protects intestinal mucosal barrier by improving intestinal flora in a murine model of sepsis

H Wang, C He, Y Liu, H Zhao, L Long, X Gai… - Biomedicine & …, 2020 - Elsevier
The study investigated the effect of soluble dietary fiber supplementation on gut microbiota,
mucosal barrier function, inflammatory markers, and survival in a murine model of sepsis …

[PDF][PDF] Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis

D Siegl, T Annecke, BL Johnson III… - …, 2014 - epub.ub.uni-muenchen.de
Background: Obesity is a growing health problem and associated with immune dysfunction.
Sepsis is defined as systemic inflammatory response syndrome that occurs during infection …

Sirtuin 2 dysregulates autophagy in high-fat-exposed immune-tolerant macrophages

S Roychowdhury, A Gandhirajan, C Kibler, X Wang… - Cells, 2021 - mdpi.com
Simple Summary SIRT2 regulates autophagy in high-fat-exposed immune cells. Abstract
Obesity increases morbidity and resource utilization in sepsis patients. The immune …