Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
PJ McLaren, C Coulonges, I Bartha… - Proceedings of the …, 2015 - National Acad Sciences
Previous genome-wide association studies (GWAS) of HIV-1–infected populations have
been underpowered to detect common variants with moderate impact on disease outcome …
been underpowered to detect common variants with moderate impact on disease outcome …
A new look at human leukocyte antigen variation in HIV; functional clustering to enhance power for discovery of host genetic associations
PJ McLaren - AIDS, 2023 - journals.lww.com
Human leukocyte antigen (HLA) class I proteins play a crucial role in the presentation of viral
peptide antigens to cytotoxic T cells during viral infection, which is necessary for mounting …
peptide antigens to cytotoxic T cells during viral infection, which is necessary for mounting …
Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study
This paper describes genetic investigations of seroreactivity to five common infectious
pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study …
pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study …
Recent advances in research of HIV infection: implications of viral and host genetics on treatment and prevention
RE Haaland, JA Johnson, J Tang - Public Health Genomics, 2013 - karger.com
The genetic diversity among human immunodeficiency virus (HIV) subtypes as well as the
variability of viral sequences found in HIV-infected individuals presents a number of difficult …
variability of viral sequences found in HIV-infected individuals presents a number of difficult …
Linkage of HIV amino acid variants to protective host alleles at CHD1L and HLA class I loci in an African population
V Schulz - 2023 - mspace.lib.umanitoba.ca
HIV viral load (VL), measured as RNA copies/mL of plasma, is a predictor of disease
progression and transmission potential. Therefore, the restriction of VL is key to achieving …
progression and transmission potential. Therefore, the restriction of VL is key to achieving …
Association of the novel susceptible locus rs9266150 with clinical features of psoriasis vulgaris in the Chinese Han population
J Wu, Y Huang, H Guo, L Ye, Y Huang… - Experimental …, 2018 - Wiley Online Library
Psoriasis is a chronic multifactorial disease and is considered to be strongly associated with
the major histocompatibility complex (MHC) region. We have discovered an independent …
the major histocompatibility complex (MHC) region. We have discovered an independent …
Host Response in HIV Infection
PJ McLaren, A Telenti - Molecular Microbiology: Diagnostic …, 2016 - Wiley Online Library
HIV is widely considered as capable of infecting all humans and of leading to relentless
disease progression. However, there is considerable diversity in human susceptibility to HIV …
disease progression. However, there is considerable diversity in human susceptibility to HIV …
[PDF][PDF] Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
DWH DG, EOJ JTH, OL GDK, SM ML, JMP DvM… - 2015 - researchportal.murdoch.edu.au
Results Genome-Wide Association Analysis. High-quality genotype data were obtained for
7,468 individuals of European ancestry from eight independent GWAS forming 10 genotype …
7,468 individuals of European ancestry from eight independent GWAS forming 10 genotype …
Investigating the role of the D0 domain of KIR3DL1 in ligand interaction and exploring the effect of LILRB1 on KIR3DL1 signaling
L Fu - 2013 - era.library.ualberta.ca
Natural killer (NK) cells are crucial in early defense against viral infections by rapidly
terminating infected cells and by secreting cytokines to shape adaptive immune responses …
terminating infected cells and by secreting cytokines to shape adaptive immune responses …