Introduction. Quality of life is a topic increasingly being addressed by researchers. Due to
the increasing incidence of colorectal cancer, this issue is particularly relevant. Despite the …

Objectives: Survey studies are a commonly used method for data collection in surgical
education research. Nevertheless, studies investigating survey design and response rates in …

Importance A watch-and-wait approach for patients with rectal cancer and a clinical
complete response after neoadjuvant chemoradiotherapy or radiotherapy is associated with …

Introduction Multimodality treatment for locally advanced rectal cancer (LARC) can include
long-course radiotherapy (LCRT) or short course radiotherapy (SCRT). Nonoperative …

Background Impairment of bowel, urogenital and fertility-related function in patients treated
for rectal cancer is common. While the rate of rectal cancer in the young (< 50 years) is …

Simple Summary Beyond the TNM-staging system, biomarkers are needed to guide cancer
treatments. We provide an overview of the Immunoscore, a standardized immune assay …

Simple Summary An individualized treatment approach is necessary to improve survival and
quality of life in rectal cancer. Tools to stratify patients are missing, but ctDNA seems to be a …

Background Deferral of conventional surgery for rectal cancer after neo-adjuvant chemo-
radiotherapy is gaining increasing interest, particularly for patients who are too frail to …

Abstract Background Circulating tumor DNA (ctDNA) is an emerging biomarker for locally
advanced rectal cancer (LARC), giving hope for stratified treatment. As the completed …

Because of the function and anatomical environment of the rectum, therapeutic strategies for
local advanced rectal cancer (LARC) must deal with two challenging stressors that are a …