Cardiac arrhythmogenesis: roles of ion channels and their functional modification

M Lei, SC Salvage, AP Jackson, CLH Huang - Frontiers in Physiology, 2024 - frontiersin.org
Cardiac arrhythmias cause significant morbidity and mortality and pose a major public
health problem. They arise from disruptions in the normally orderly propagation of cardiac …

Cardiomyocyte electrophysiology and its modulation: current views and future prospects

CLH Huang, M Lei - … Transactions of the Royal Society B, 2023 - royalsocietypublishing.org
Normal and abnormal cardiac rhythms are of key physiological and clinical interest. This
introductory article begins from Sylvio Weidmann's key historic 1950s microelectrode …

Non-canonical role of the sympathetic nervous system in the day–night rhythm in heart rate

C Anderson, G Forte, W Hu… - … of the Royal …, 2023 - royalsocietypublishing.org
Although, for many decades, the day–night rhythm in resting heart rate has been attributed
to the parasympathetic branch of the autonomic nervous system (high vagal tone during …

Aligned nanofibrous net deposited perpendicularly on microridges supports endothelium formation and promotes the structural maturation of hiPSC-derived …

F Tian, L Yin, P Lin, Y Liu, W Wang… - ACS Applied Materials …, 2023 - ACS Publications
Cell alignment widely exists in various in vivo tissues and also plays an essential role in the
construction of in vitro models, such as vascular endothelial and myocardial models …

Identification of early biomarkers in saliva in genetically engineered mouse model C (3) 1-TAg of breast cancer

IF Gilson Sena, LL Fernandes, LL Lorandi… - Scientific Reports, 2022 - nature.com
Breast cancer is one of leading causes of death worldwide in the female population. Deaths
from breast cancer could be reduced significantly through earlier and more efficient …

Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart

MB Dial, EM Malek, GA Neblina, AR Cooper… - Scientific Reports, 2024 - nature.com
Circadian rhythms play a crucial role in the regulation of various physiological processes,
including cardiovascular function and metabolism. Exercise provokes numerous beneficial …

Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression

PAC Costa, WN Silva, PHDM Prazeres… - Acta neuropathologica …, 2021 - Springer
Sensory neurons have recently emerged as components of the tumor microenvironment.
Nevertheless, whether sensory neuronal activity is important for tumor progression remains …

β-Adrenergic signaling drives structural and functional maturation of mouse cardiomyocytes

M Eliezeck, IC Guedes Jesus… - … of Physiology-Cell …, 2024 - journals.physiology.org
Cardiac maturation represents the last phase of heart development and is characterized by
morphofunctional alterations that optimize the heart for efficient pumping. Its understanding …

Time of day affects MrgD-dependent modulation of cardiomyocyte contractility

ALL Monteiro, M Eliezeck… - … of Physiology-Cell …, 2024 - journals.physiology.org
The renin-angiotensin system (RAS) is composed of a series of peptides, receptors, and
enzymes that play a pivotal role in maintaining cardiovascular homeostasis. Among the most …

Sympathetic nerve-adipocyte interactions in response to acute stress

GSP Santos, AC Costa, CC Picoli, BGS Rocha… - Journal of Molecular …, 2022 - Springer
Psychological stress predisposes our body to several disorders. Understanding the cellular
and molecular mechanisms involved in the physiological responses to psychological stress …