MALDI Imaging mass spectrometry has entered the field of tissue-based research by
providing unique advantages for analyzing tissue specimen in an unprecedented detail. A …

In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …

Background & Aims Prothrombin induced by vitamin K absence-II (PIVKA-II) is a diagnostic
and surveillance marker for HCC mainly used in Asia, and has also been shown to be a …

Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is an independent
predictor of poor outcomes subsequent to surgical resection or liver transplantation (LT); …

Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful technology used to investigate the spatial distributions of thousands of molecules …

Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

MALDI mass spectrometry imaging is able to simultaneously determine the spatial
distribution of hundreds of molecules directly from tissue sections, without labeling and …

Background & Aims Hepatocellular carcinoma (HCC) is one of the most common
malignancies worldwide. However, the detailed molecular mechanisms underlying HCC …

Abstract Background Microvascular invasion (MiVI) is a major risk factor of survival
outcomes after curative resection for patients with hepatocellular carcinoma (HCC). This …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …