Cyclic decidualization of the human endometrium in reproductive health and failure

B Gellersen, JJ Brosens - Endocrine reviews, 2014 - academic.oup.com
Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

[HTML][HTML] Molecular aspects of implantation failure

YEM Koot, G Teklenburg, MS Salker, JJ Brosens… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Despite expanding global experience with advanced reproductive technologies, the majority
of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation …

GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells

DQ Tran, J Andersson, R Wang… - Proceedings of the …, 2009 - National Acad Sciences
TGF-β family members are highly pleiotropic cytokines with diverse regulatory functions.
TGF-β is normally found in the latent form associated with latency-associated peptide (LAP) …

MicroRNAs are associated with human embryo implantation defects

A Revel, H Achache, J Stevens, Y Smith… - Human …, 2011 - academic.oup.com
BACKGROUND Repeated implantation failure (RIF) is a major problem encountered in IVF.
We have previously reported that RIF-IVF patients have a different endometrial gene …

DNA methylation and recurrent pregnancy loss: a mysterious compass?

Q Zhou, Y Xiong, B Qu, A Bao, Y Zhang - Frontiers in immunology, 2021 - frontiersin.org
Recurrent pregnancy loss (RPL) is a common and severe pathological pregnancy, whose
pathogenesis is not fully understood. With the development of epigenetics, the study of DNA …

ARID1A Mutations and PI3K/AKT Pathway Alterations in Endometriosis and Endometriosis-Associated Ovarian Carcinomas

EP Samartzis, A Noske, KJ Dedes, D Fink… - International journal of …, 2013 - mdpi.com
Endometriosis is a common gynecological disease affecting 6%–10% of women of
reproductive age and is characterized by the presence of endometrial-like tissue in …

Deregulation of the serum-and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure

MS Salker, M Christian, JH Steel, J Nautiyal, S Lavery… - Nature medicine, 2011 - nature.com
Infertility and recurrent pregnancy loss (RPL) are prevalent but distinct causes of
reproductive failure that often remain unexplained despite extensive investigations …

Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility

S Altmäe, JA Martinez-Conejero… - MHR: Basic science …, 2009 - academic.oup.com
Successful embryo implantation depends on the quality of the embryo, as well as on the
receptivity of the endometrium. The aim of this study was to investigate the endometrial gene …

Potential significance of physiological and pharmacological glucocorticoids in early pregnancy

AE Michael, AT Papageorghiou - Human reproduction update, 2008 - academic.oup.com
BACKGROUND Despite extensive studies of the developmental consequences of increased
glucocorticoid exposure in mid-to late pregnancy, relatively little is known regarding the …

Increased activation of the PI3K/AKT pathway compromises decidualization of stromal cells from endometriosis

X Yin, ME Pavone, Z Lu, JJ Wei… - The Journal of Clinical …, 2012 - academic.oup.com
Context: Endometriosis affects approximately 10% of women in the United States and
causes pain and infertility. Decidualization of endometrial stromal cells from women with …