Functionalized Nanomaterials for Inhibiting ATP-Dependent Heat Shock Proteins in Cancer Photothermal/Photodynamic Therapy and Combination Therapy
Phototherapies induced by photoactive nanomaterials have inspired and accentuated the
importance of nanomedicine in cancer therapy in recent years. During these light-activated …
importance of nanomedicine in cancer therapy in recent years. During these light-activated …
Development of a first-in-class small-molecule inhibitor of the C-terminal Hsp90 dimerization
Heat shock proteins 90 (Hsp90) are promising therapeutic targets due to their involvement in
stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression …
stabilizing several aberrantly expressed oncoproteins. In cancerous cells, Hsp90 expression …
Mitochondria-mediated HSP inhibition strategy for enhanced low-temperature photothermal therapy
W Liu, J Di, Y Ma, S Wang, M Meng, Y Yin… - … Applied Materials & …, 2023 - ACS Publications
Low-temperature photothermal therapy (PTT) has the advantage of causing less damage to
normal tissues and has attracted great attention in recent years. However, the efficacy of low …
normal tissues and has attracted great attention in recent years. However, the efficacy of low …
Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach
JR McConnell, LK Buckton, SR McAlpine - Bioorganic & medicinal …, 2015 - Elsevier
Described is the role that heat shock factor 1 (HSF1) plays in regulating cellular stress.
Focusing on the current state of the HSF1 field in chemotherapeutics we outline the …
Focusing on the current state of the HSF1 field in chemotherapeutics we outline the …
Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response
Abstract Heat shock protein 90 (HSP90) stabilizes many client proteins, including the BCR-
ABL1 oncoprotein. BCR-ABL1 is the hallmark of chronic myeloid leukemia (CML) in which …
ABL1 oncoprotein. BCR-ABL1 is the hallmark of chronic myeloid leukemia (CML) in which …
Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells
M Vogt, N Dienstbier, J Schliehe-Diecks… - Cell Death & …, 2023 - nature.com
HSP90 has emerged as an appealing anti-cancer target. However, HSP90 inhibitors
(HSP90i) are characterized by limited clinical utility, primarily due to the resistance …
(HSP90i) are characterized by limited clinical utility, primarily due to the resistance …
Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma
Background There is no universally accepted treatment for patients with advanced papillary
renal cell carcinoma (PRCC). The presence of activating mutations in MET, as well as gain …
renal cell carcinoma (PRCC). The presence of activating mutations in MET, as well as gain …
Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway
Morphine and other opioids are commonly used to treat pain despite their numerous
adverse side effects. Modulating μ-opioid receptor (MOR) signaling is one way to potentially …
adverse side effects. Modulating μ-opioid receptor (MOR) signaling is one way to potentially …
[HTML][HTML] Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2
L Pesonen, S Svartsjö, V Bäck, A de Thonel… - Cell Stress and …, 2021 - Elsevier
Cancer cells rely on heat shock proteins (HSPs) for growth and survival. Especially HSP90
has multiple client proteins and plays a critical role in malignant transformation, and …
has multiple client proteins and plays a critical role in malignant transformation, and …
Bis-aryl-α, β-unsaturated ketone (ABK) chaperonin inhibitors exhibit selective cytotoxicity to colorectal cancer cells that correlates with levels of aberrant HSP60 in the …
While many studies have established the importance of protein homeostasis in tumor
progression, little effort has been made to examine the therapeutic potential of targeting the …
progression, little effort has been made to examine the therapeutic potential of targeting the …