The large number of ion channels found in all nervous systems poses fundamental
questions concerning how the characteristic intrinsic properties of single neurons are …

Injuries to the peripheral nerves result in partial or total loss of motor, sensory and autonomic
functions conveyed by the lesioned nerves to the denervated segments of the body, due to …

The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …

Background In the not-too-distant past, the dorsal root ganglion (DRG) was portrayed as a
passive neural structure without involvement in the development or maintenance of chronic …

Ectopic discharge in axotomized dorsal root ganglion neurons is a key driver of neuropathic
pain. However, the bulk of this activity is generated and carried centrally in large diameter …

At specific stages of development, nerve and muscle cells generate spontaneous electrical
activity that is required for normal maturation of intrinsic excitability and synaptic connectivity …

Although skeletal pain is a leading cause of chronic pain and disability, relatively little is
known about the specific populations of nerve fibers that innervate the skeleton. Recent …

Peripheral nerve injury causes neuropathic pain, which is characterized by the paradoxical
sensations of positive and negative symptoms. Clinically, negative signs are frequently …

Although ion channels are increasingly being discovered in cancer cells in vitro and in vivo,
and shown to contribute to different aspects and stages of the cancer process, much less is …

We have shown previously that voltage‐gated Na+ channels (VGSCs) are up‐regulated in
human metastatic disease (prostate, breast and small‐cell lung cancers), and that VGSC …