Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

Cellular and organism survival depends upon the regulation of pH, which is regulated by
highly specialized cell membrane transporters, the solute carriers (SLC)(For a …

Bicarbonate is one of the major anions in mammalian tissues and extracellular fluids. Along
with accompanying H+, HCO 3-is generated from CO 2 and H 2 O, either spontaneously or …

Cardiac tissue ischemia/hypoxia increases glycolysis and lactic acid accumulation in
cardiomyocytes, leading to intracellular metabolic acidosis. Sodium bicarbonate …

Our objective was to examine the effects of N-methylacetazolamide (NMA), a non‑carbonic
anhydrase inhibitor, on ischemia-reperfusion injury. Isolated rat hearts were assigned to the …

Congenital proximal renal tubular acidosis (pRTA) is a rare systemic disease caused by
mutations in the SLC4A4 gene that encodes the electrogenic sodium bicarbonate …

Background Although the participation of the electrogenic sodium/bicarbonate cotransporter
(NBCe1) in the recovery from an intracellular acid load is recognized, its role in ischemia …

Bicarbonate transporters are responsible for the appropriate flux of bicarbonate across the
plasma membrane to perform various fundamental cellular functions. The functions of …

Abstract NBC Na+/HCO 3− cotransporter (NBCn1) and NHE1 Na+/H+ exchanger have been
associated with cardiac disorders and recently located in coronary endothelial cells (CEC) …

Cardiac contractile strength is recognised as being highly pH-sensitive, but less is known
about the influence of pH on cardiac gene expression, which may become relevant in …