Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

Seizure activity in the hippocampal region strongly affects stem cell-associated plasticity in
the adult dentate gyrus. Here, we describe how seizures in rodent models of mesial …

Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …

Dentate granule cell (DGC) neurogenesis persists throughout life in the hippocampal
dentate gyrus. In rodent temporal lobe epilepsy models, status epilepticus (SE) stimulates …

Epilepsy and depression share an unusually high coincidence suggestive of a common
etiology. Disrupted production of adult-born hippocampal granule cells in both disorders …

Background Traumatic brain injury (TBI) occurs in as many as 64–74 million people
worldwide each year and often results in one or more post-traumatic syndromes, including …

Neuroprotection is increasingly considered as a promising therapy for preventing and
treating temporal lobe epilepsy (TLE). The development of chronic TLE, also termed as …

In April 2004, a group of physicians with an interest in nonconvulsive status epilepticus
representing a spectrum of opinion met in Oxford, sponsored by the Epilepsy Research …

Virtually all mammals, including humans, exhibit neurogenesis throughout life in the
hippocampus, a learning and memory center in the brain. Numerous studies in animal …

Aberrantly interconnected granule cells are characteristic of temporal lobe epilepsy. By
reducing network stability, these abnormal neurons may contribute directly to disease …