Arsenic exposure promotes the emergence of cardiovascular diseases

C Karachaliou, A Sgourou, S Kakkos… - Reviews on …, 2022 - degruyter.com
A large number of studies conducted in the past decade 2010–2020 refer to the impact of
arsenic (As) exposure on cardiovascular risk factors. The arsenic effect on humans is …

AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance

T Qiu, C Wu, X Yao, Q Han, N Wang, W Yuan… - Cell Biology and …, 2023 - Springer
Abstract N6-methyladenosine (m6A) messenger RNA methylation is the most widespread
gene regulatory mechanism affecting liver functions and disorders. However, the …

Interactions of arsenic metabolism with arsenic exposure and individual factors on diabetes occurrence: Baseline findings from Arsenic and Non-Communicable …

Q Zhang, Y Hou, D Wang, Y Xu, H Wang, J Liu… - Environmental …, 2020 - Elsevier
The interaction between arsenic metabolism and potential modifiers on the risk of diabetes
is unclear. This research aimed to investigate arsenic metabolism and diabetes prevalence …

[HTML][HTML] Arsenic inorganic exposure, metabolism, genetic biomarkers and its impact on human health: A mini-review

F González-Martínez, B Johnson-Restrepo… - Toxicology Letters, 2024 - Elsevier
Inorganic arsenic species exist in the environment as a result of both natural sources, such
as volcanic and geothermal activities, and geological formations, as well as anthropogenic …

Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women

X Liang, G Guo, Y Wang, M Wang, X Chen… - Environmental …, 2023 - Elsevier
Abstract Background Single nucleotide polymorphisms (SNPs) in N6AMT1 and AS3MT are
associated with arsenic (As) metabolism, and efficient As methylation capacity has been …

As3MT and GST polymorphisms influencing arsenic metabolism in human exposure to drinking groundwater

F González-Martínez, D Sánchez-Rodas… - International Journal of …, 2020 - mdpi.com
The urinary arsenic metabolites may vary among individuals and the genetic factors have
been reported to explain part of the variation. We assessed the influence of polymorphic …

Multi-generational impacts of arsenic exposure on genome-wide DNA methylation and the implications for arsenic-induced skin lesions

X Guo, X Chen, J Wang, Z Liu, D Gaile, H Wu… - Environment …, 2018 - Elsevier
As a nonmutagenic human carcinogen, arsenic (As)'s carcinogenic activity is likely the result
of epigenetic changes, particularly alterations in DNA methylation. While increasing studies …

Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N‐6 adenine‐specific DNA methyltransferase 1 (N6AMT1) polymorphisms …

R De la Rosa, C Steinmaus, NK Akers… - Environmental and …, 2017 - Wiley Online Library
Inter‐individual differences in arsenic metabolism have been linked to arsenic‐related
disease risks. Arsenic (+ 3) methyltransferase (AS3MT) is the primary enzyme involved in …

[HTML][HTML] Arsenic metabolites; selenium; and AS3MT, MTHFR, AQP4, AQP9, SELENOP, INMT, and MT2A polymorphisms in Croatian-Slovenian population from PHIME …

A Stajnko, Z Šlejkovec, D Mazej, A France-Štiglic… - Environmental …, 2019 - Elsevier
The relationships between inorganic arsenic (iAs) metabolism, selenium (Se) status, and
genetic polymorphisms of various genes, commonly studied in populations exposed to high …

The methyltransferase N6AMT1 participates in the cell cycle by regulating cyclin E levels

M Mutso, B Brūmele, E Serova, F Väärtnõu, M Suija… - Plos one, 2024 - journals.plos.org
The methyltransferase N6AMT1 has been associated with the progression of different
pathological conditions, such as tumours and neurological malfunctions, but the underlying …