[HTML][HTML] Pattern formation mechanisms of self-organizing reaction-diffusion systems
Embryonic development is a largely self-organizing process, in which the adult body plan
arises from a ball of cells with initially nearly equal potency. The reaction-diffusion theory first …
arises from a ball of cells with initially nearly equal potency. The reaction-diffusion theory first …
Self-organization principles of intracellular pattern formation
Dynamic patterning of specific proteins is essential for the spatio-temporal regulation of
many important intracellular processes in prokaryotes, eukaryotes and multicellular …
many important intracellular processes in prokaryotes, eukaryotes and multicellular …
Rethinking pattern formation in reaction–diffusion systems
The present theoretical framework for the analysis of pattern formation in complex systems is
mostly limited to the vicinity of fixed (global) equilibria. Here we present a new theoretical …
mostly limited to the vicinity of fixed (global) equilibria. Here we present a new theoretical …
Developmental clock and mechanism of de novo polarization of the mouse embryo
INTRODUCTION During preimplantation development, the establishment of apicobasal cell
polarity is key for the transition from totipotency to pluripotency, which induces cell …
polarity is key for the transition from totipotency to pluripotency, which induces cell …
Guiding self-organized pattern formation in cell polarity establishment
Spontaneous pattern formation in Turing systems relies on feedback. But patterns in cells
and tissues seldom form spontaneously—instead they are controlled by regulatory …
and tissues seldom form spontaneously—instead they are controlled by regulatory …
Many roads to symmetry breaking: molecular mechanisms and theoretical models of yeast cell polarity
AB Goryachev, M Leda - Molecular biology of the cell, 2017 - Am Soc Cell Biol
Mathematical modeling has been instrumental in identifying common principles of cell
polarity across diverse systems. These principles include positive feedback loops that are …
polarity across diverse systems. These principles include positive feedback loops that are …
Phase-space geometry of mass-conserving reaction-diffusion dynamics
Experimental studies of protein-pattern formation have stimulated new interest in the
dynamics of reaction-diffusion systems. However, a comprehensive theoretical …
dynamics of reaction-diffusion systems. However, a comprehensive theoretical …
A cell-size threshold limits cell polarity and asymmetric division potential
Reaction–diffusion networks underlie pattern formation in a range of biological contexts,
from morphogenesis of organisms to the polarization of individual cells. One requirement for …
from morphogenesis of organisms to the polarization of individual cells. One requirement for …
Principles that govern competition or co-existence in Rho-GTPase driven polarization
JG Chiou, SA Ramirez, TC Elston… - PLoS computational …, 2018 - journals.plos.org
Rho-GTPases are master regulators of polarity establishment and cell morphology. Positive
feedback enables concentration of Rho-GTPases into clusters at the cell cortex, from where …
feedback enables concentration of Rho-GTPases into clusters at the cell cortex, from where …
Cells use molecular working memory to navigate in changing chemoattractant fields
In order to migrate over large distances, cells within tissues and organisms rely on sensing
local gradient cues which are irregular, conflicting, and changing over time and space. The …
local gradient cues which are irregular, conflicting, and changing over time and space. The …