Melanoma is the most aggressive form of skin cancer owing to its high propensity to
metastasise in distant organs and develop resistance to treatment. The scarce treatment …

Abstract Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and
coagulation. It is also present in endothelial cells (ECs) and the extracellular matrix (ECM) …

Background Gastric cancer is one of the deadliest cancers, currently available therapies
have limited success. Cancer-associated fibroblasts (CAFs) are pivotal cells in the stroma of …

Background The contribution of the tumor microenvironment and extracellular matrix to the
aggressive biology of Gastric Cancer (GC) has been recently characterized; however, the …

Background Currently, the prognosis of patients with non-small cell lung cancer (NSCLC)
remains unsatisfactory. This current study evaluated the relationship between histology of …

Gastric cancer (GC) is the most common cancer worldwide and the third leading cause of
cancer death, with the fifth highest incidence. The development of effective …

Advancing age is a negative prognostic factor for cutaneous melanoma. However, the role of
extracellular vesicles (EVs) within the melanoma tumor microenvironment (TME) has …

In healthy individuals, physical exercise improves cardiovascular health and muscle
strength, alleviates fatigue and reduces the risk of chronic diseases. Although exercise is …

Tumor-derived exosomes (TEX) are a subset of small extracellular vesicles (sEV) present in
all body fluids of patients with cancer. In plasma of patients with metastatic melanoma …

The extracellular matrix (ECM) is an important component of the tumor microenvironment
and undergoes extensive remodeling during both initiation and progression of breast cancer …