The degradation of damaged proteins is critical for tissue integrity and organismal health
because damaged proteins have a high propensity to form aggregates. E3 ubiquitin ligases …

Abstract Doa10 (MARCHF6 in metazoans) is a large polytopic membrane-embedded E3
ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality …

Selective protein degradation typically involves substrate recognition via short linear motifs
known as degrons. Various degrons can be found at protein termini from bacteria to …

Corneal endothelial cells, situated on the innermost layer of the cornea, are vital for
maintaining its clarity and thickness by regulating fluid. In this study, we investigated the …

Novel proteins can originate de novo from non-coding DNA and contribute to species-
specific adaptations. It is challenging to conceive how de novo emerging proteins may …