Three DNA polymerases are thought to function at the eukaryotic DNA replication fork.
Currently, a coherent model has been derived for the composition and activities of the …

DNA primase synthesizes short RNA primers that replicative polymerases further elongate in
order to initiate the synthesis of all new DNA strands. Thus, primase owes its existence to the …

The human primosome, a 340-kilodalton complex of primase and DNA polymerase α (Polα),
synthesizes chimeric RNA-DNA primers to be extended by replicative DNA polymerases δ …

The synthesis of RNA–DNA primer by primosome requires coordination between primase
and DNA polymerase α subunits, which is accompanied by unknown architectural …

Primases synthesize the RNA primers that are necessary for replication of the parental DNA
strands. Here we report that the heterodimeric archaeal/eukaryotic primase is an iron-sulfur …

Telomere maintenance is essential for the genome integrity of eukaryotes, and this function
is underpinned by the two-step telomeric DNA synthesis process: telomere G-overhang …

Eukaryotic DNA primase initiates the synthesis of all new DNA strands by synthesizing short
RNA oligomers on single-stranded DNA. Additionally, primase helps couple replication and …

DNA primase synthesizes short RNA primers that are required to initiate DNA synthesis on
the parental template strands during DNA replication. Eukaryotic primase contains two …

DNA replication in eukaryotes relies on the synthesis of a∼ 30-nucleotide RNA/DNA primer
strand through the dual action of the heterotetrameric polymerase α-primase (pol-prim) …

DNA replication in bacteria and eukaryotes requires the activity of DNA primase, a DNA-
dependent RNA polymerase that lays short RNA primers for DNA polymerases. Eukaryotic …