Forced degradation studies of biopharmaceuticals: Selection of stress conditions
Stability studies under stress conditions or forced degradation studies play an important role
in different phases of development and production of biopharmaceuticals and biological …
in different phases of development and production of biopharmaceuticals and biological …
Accelerated formulation development of monoclonal antibodies (mAbs) and mAb-based modalities: review of methods and tools
VI Razinkov, MJ Treuheit… - Journal of biomolecular …, 2015 - journals.sagepub.com
More therapeutic monoclonal antibodies and antibody-based modalities are in development
today than ever before, and a faster and more accurate drug discovery process will ensure …
today than ever before, and a faster and more accurate drug discovery process will ensure …
Artificial nacre-like papers based on noncovalent functionalized boron nitride nanosheets with excellent mechanical and thermally conductive properties
Inspired by the nano/microscale hierarchical structure and the precise inorganic/organic
interface of natural nacre, we fabricated artificial nacre-like papers based on noncovalent …
interface of natural nacre, we fabricated artificial nacre-like papers based on noncovalent …
Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions
IgG1 mAb solutions were prepared with and without sodium chloride and subjected to
different environmental stresses. Formation of aggregates and particles of varying size was …
different environmental stresses. Formation of aggregates and particles of varying size was …
Evaluating the role of the air-solution interface on the mechanism of subvisible particle formation caused by mechanical agitation for an IgG1 mAb
Mechanical agitation of monoclonal antibody (mAb) solutions often leads to protein particle
formation. In this study, various formulations of an immunoglobulin G (IgG) 1 mAb were …
formation. In this study, various formulations of an immunoglobulin G (IgG) 1 mAb were …
Leaf photosynthesis and senescence in heated and droughted field-grown soybean with contrasting seed protein concentration
Soybean plants under heat and drought generate a multiplicity of responses in
photosynthesis and senescence, impairing growth, yield, and seed quality. The goal of this …
photosynthesis and senescence, impairing growth, yield, and seed quality. The goal of this …
Subvisible (2–100 μm) particle analysis during biotherapeutic drug product development: Part 2, experience with the application of subvisible particle analysis
V Corvari, LO Narhi, TM Spitznagel, N Afonina, S Cao… - Biologicals, 2015 - Elsevier
Measurement and characterization of subvisible particles (including proteinaceous and non-
proteinaceous particulate matter) is an important aspect of the pharmaceutical development …
proteinaceous particulate matter) is an important aspect of the pharmaceutical development …
Effects of protein conformation, apparent solubility, and protein–protein interactions on the rates and mechanisms of aggregation for an IgG1Monoclonal antibody
Non-native protein aggregation is a key degradation pathway of immunoglobulins. In this
work, the aggregation kinetics of an immunoglobulin gamma-1 monoclonal antibody (IgG1 …
work, the aggregation kinetics of an immunoglobulin gamma-1 monoclonal antibody (IgG1 …
A new method for nondestructive quality evaluation of the resistance spot welding based on the radar chart method and the decision tree classifier
H Zhang, Y Hou, J Zhang, X Qi, F Wang - The International Journal of …, 2015 - Springer
To develop an effective nondestructive evaluation method for the welding quality of the
resistance spot welding, the electrode displacement signal during the resistance spot …
resistance spot welding, the electrode displacement signal during the resistance spot …
Characterization of the physical stability of a lyophilized IgG1 mAb after accelerated shipping-like stress
S Telikepalli, OS Kumru, JH Kim, SB Joshi… - Journal of …, 2015 - Elsevier
Upon exposure to shaking stress, an IgG1 mAb formulation in both the liquid and lyophilized
state formed subvisible particles. Because freeze-drying was expected to minimize protein …
state formed subvisible particles. Because freeze-drying was expected to minimize protein …