In living cells, growth is the result of coupling between substrate catabolism and multiple
metabolic processes that take place during net biomass formation and maintenance …

The Warburg effect is the long-standing riddle of cancer biology. How does aerobic
glycolysis, inefficient in producing ATP, confer a growth advantage to cancer cells? A new …

Saccharomyces cerevisiae cells in the exponential phase sustain their growth by producing
ATP through fermentation and/or mitochondrial respiration. The fermentable carbon …

Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where
it performs several functions. In normal cells, citrate sustains protein acetylation, lipid …

Saccharomyces cerevisiae, Baker's yeast, is the industrial workhorse for producing ethanol
and the subject of substantial metabolic engineering research in both industry and …

The Crabtree effect is defined as a rapid glucose-induced repression of mitochondrial
oxidative metabolism and has been described in yeasts and tumor cells. Using plate-based …

Microbial metabolism is a fundamental cellular process that involves many biochemical
events and is distinguished by its emergent properties. While the molecular details of …

Increased glycolytic flux is a hallmark of cancer; however, an increasing body of evidence
indicates that glycolytic ATP production may be dispensable in cancer, as metabolic …

Bioconversion of lignocellulosic biomass into ethanol requires efficient xylose fermentation.
Previously, we developed an engineered Saccharomyces cerevisiae strain, named SR8 …

Among the components of the blood–brain barrier (BBB), endothelial cells (ECs) play an
important role in supplying limited materials, especially glucose, to the brain. However, the …