Newton's third law of motion states that for every action on a physical object there is an
equal and opposite reaction. The dynamic change in functional potential of natural killer …

It has been known for more than 30 years that HIV-1 infection drives a very potent B cell
response resulting in the production of anti-HIV-1 antibodies targeting several viral proteins …

Interactions between human leukocyte antigen (HLA) molecules on target cells and the
inhibitory killer cell immunoglobulin-like receptors (KIRs) and heterodimeric inhibitory …

Mice lacking MHC class-I (MHC-I) display severe defects in natural killer (NK) cell functional
maturation, a process designated as “education”. Whether self-MHC-I specific Ly49 family …

Natural killer (NK) cells are functionally tuned by education via killer cell immunoglobulin
receptors (KIRs) interacting with HLA class I molecules. We examined the effect of KIR gene …

NK cells expressing self-inhibitory receptors display increased functionality compared to NK
cells lacking those receptors. The acquisition of functional competence in these particular …

NK cells are innate lymphocytes with protective functions against viral infections and tumor
formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which …

Natural killer (NK) cells deliver cytotoxic granules and immunomodulatory cytokines in
response to transformed and virally infected cells. NK cell functions are under the control of …

Natural killer (NK) cells provide essential protection against viral infections. One of the
defining features of this lymphocyte population is the expression of a wide array of variable …

Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors
(KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands …