The recent outbreak of the corona virus disease (COVID-19) has had major global impact.
The relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) …

Nitric oxide has been known to play a significant role in the pathophysiology of various
disorders of the body. Despite its very short half-life, nitric oxide is known to modulate …

Sexual dysfunction often accompanies severe psychiatric illness and can be due to both the
mental disorder itself and the use of psychotropic treatments. Many sexual symptoms …

Introduction: Depression is one of the most prevalent and life-threatening forms of mental
illness associated with significant disability and mortality. About 21% of the world's …

Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes that are
involved in the regulation of the intracellular second messengers cyclic AMP (cAMP) and …

Sepsis is a systemic inflammatory response to infection and a major cause of morbidity and
mortality. Sildenafil (SLD) is a selective and potent inhibitor of cyclic guanosine …

Affective and anxiety disorders are widely distributed disorders with severe social and
economic effects. Evidence is emphatic that effective treatment helps to restore function and …

The corticostriatal and hippocampal circuits contribute to the neurobiological underpinnings
of several neuropsychiatric disorders, including Alzheimer's disease, Parkinson's disease …

Although lithium has largely met its initial promise as the first drug discovered in the modern
era of psychopharmacology, to date no definitive mechanism for its effects has been …

Pleasurable sexual activity is important in many human relationships and can provide a
sense of physical, emotional and social well-being. Depressive symptoms and depressive …