P4-ATPases as phospholipid flippases—structure, function, and enigmas
JP Andersen, AL Vestergaard, SA Mikkelsen… - Frontiers in …, 2016 - frontiersin.org
P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids
across cell membranes. This generates and maintains membrane lipid asymmetry, a …
across cell membranes. This generates and maintains membrane lipid asymmetry, a …
ARF family G proteins and their regulators: roles in membrane transport, development and disease
JG Donaldson, CL Jackson - Nature reviews Molecular cell biology, 2011 - nature.com
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …
Cryo-EM structures capture the transport cycle of the P4-ATPase flippase
M Hiraizumi, K Yamashita, T Nishizawa, O Nureki - Science, 2019 - science.org
In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …
Protein Sorting at the trans-Golgi Network
The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …
Structure and autoregulation of a P4-ATPase lipid flippase
Abstract Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active
transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of …
transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of …
Phosphatidylserine transport in cell life and death
Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …
Phospholipid flippases: building asymmetric membranes and transport vesicles
TT Sebastian, RD Baldridge, P Xu… - Biochimica et Biophysica …, 2012 - Elsevier
Phospholipid flippases in the type IV P-type ATPase family (P4-ATPases) are essential
components of the Golgi, plasma membrane and endosomal system that play critical roles in …
components of the Golgi, plasma membrane and endosomal system that play critical roles in …
Interplay of proteins and lipids in generating membrane curvature
The majority of intracellular membranes have strongly bent shapes with radii of curvature
ranging from 20 to 50nm. Many different proteins provide the substantial energy needed to …
ranging from 20 to 50nm. Many different proteins provide the substantial energy needed to …
Mammalian P4-ATPases and ABC transporters and their role in phospholipid transport
JA Coleman, F Quazi, RS Molday - … et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Transport of phospholipids across cell membranes plays a key role in a wide variety of
biological processes. These include membrane biosynthesis, generation and maintenance …
biological processes. These include membrane biosynthesis, generation and maintenance …
Coordination of Golgi functions by phosphatidylinositol 4-kinases
TR Graham, CG Burd - Trends in cell biology, 2011 - cell.com
Phosphatidylinositol 4-kinases (PI4Ks) regulate vesicle-mediated export from the Golgi
apparatus via phosphatidylinositol 4-phosphate (PtdIns4P) binding effector proteins that …
apparatus via phosphatidylinositol 4-phosphate (PtdIns4P) binding effector proteins that …