[HTML][HTML] Crosstalkr: An open-source R package to facilitate drug target identification

DT Weaver, JG Scott - bioRxiv, 2023 - ncbi.nlm.nih.gov
In the last few decades, interest in graph-based analysis of biological networks has grown
substantially. Protein-protein interaction networks are one of the most common biological …

Novel approaches for optimal therapy design in drug-resistant populations

DT Weaver - 2023 - search.proquest.com
The current maximum tolerated dose treatment paradigm for cancer and bacteria fails to
account for the capacity of these disease agents to evolve. When treatment fails to achieve …

Identifying Significantly Perturbed Subnetworks in Cancer Using Multiple Protein–Protein Interaction Networks

L Yang, R Chen, T Melendy, S Goodison, Y Sun - Cancers, 2023 - mdpi.com
Simple Summary Cancer research has been increasingly focusing on identifying genes and
molecular pathways that drive the disease. In this context, protein–protein interaction …

Rethinking Cancer Gene Identification through Graph Anomaly Analysis

Y Zang, L Ren, Y Li, Z Wang, DA Selby, Z Wang… - arXiv preprint arXiv …, 2024 - arxiv.org
Graph neural networks (GNNs) have shown promise in integrating protein-protein
interaction (PPI) networks for identifying cancer genes in recent studies. However, due to the …

Construction of gene coexpression networks and transcriptomic analysis for Rhizobium leguminosarum

J Pardo Díaz - 2022 - ora.ox.ac.uk
Rhizobium leguminosarum is a soil bacteria which infects plants of the legume family such
as peas, lentils, and beans. When associated with the plant, R. leguminosarum fixes …