The mammalian nervous system is comprised of a seemingly infinitely complex network of
specialized synaptic connections that coordinate the flow of information through it. The field …

Understanding the principles of information processing in neural circuits requires systematic
characterization of the participating cell types and their connections, and the ability to …

Two-photon calcium imaging is a powerful means for monitoring the activity of distinct
neurons in brain tissue in vivo. In the mammalian brain, such imaging studies have been …

To visualize odorant representations by receptor neuron input to the mouse olfactory bulb,
we loaded receptor neurons with calcium-sensitive dye and imaged odorant-evoked …

The study of neural circuits requires methods for simultaneously recording the activity of
populations of neurons. Here, using calcium imaging of neocortical brain slices we take …

Genetically encoded optical actuators and indicators have changed the landscape of
neuroscience, enabling targetable control and readout of specific components of intact …

Most animals depend on the identification of odours to locate food or to find mating partners.
To accomplish this, the olfactory system must recognize relative concentrations of a large …

The design and engineering of organic fluorescent Ca2+ indicators approximately 30 years
ago opened the door for imaging cellular Ca2+ signals with a high degree of temporal and …

Although vertebrate hindbrains are segmented structures, the functional significance of the
segmentation is unknown. In zebrafish, the hindbrain segments contain serially repeated …

Odor information is first represented in the brain by patterns of input activity across the
glomeruli of the olfactory bulb (OB). To examine how odorants are represented at this stage …