[HTML][HTML] The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
M Cordenonsi, F Zanconato, L Azzolin, M Forcato… - Cell, 2011 - cell.com
Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …
understanding of the cellular and molecular mechanisms that underlie CSC properties is …
[HTML][HTML] A MicroRNA targeting dicer for metastasis control
Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA
downregulation is a common trait of human malignancies. The mechanisms of this …
downregulation is a common trait of human malignancies. The mechanisms of this …
Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential
Background Development of human cancer can proceed through the accumulation of
different genetic changes affecting the structure and function of the genome. Combined …
different genetic changes affecting the structure and function of the genome. Combined …
Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data
ML Kuijjer, H Rydbeck, SH Kresse… - Genes …, 2012 - Wiley Online Library
High‐grade osteosarcoma is a tumor with a complex genomic profile, occurring primarily in
adolescents with a second peak at middle age. The extensive genomic alterations obscure …
adolescents with a second peak at middle age. The extensive genomic alterations obscure …
Prospective biomarker analysis of the randomized CHER-LOB study evaluating the dual anti-HER2 treatment with trastuzumab and lapatinib plus chemotherapy as …
V Guarneri, MV Dieci, A Frassoldati, A Maiorana… - The …, 2015 - academic.oup.com
Abstract Background. The CHER-LOB randomized phase II study showed that the
combination of lapatinib and trastuzumab plus chemotherapy increases the pathologic …
combination of lapatinib and trastuzumab plus chemotherapy increases the pathologic …
Efficient weighted univariate clustering maps outstanding dysregulated genomic zones in human cancers
Motivation Chromosomal patterning of gene expression in cancer can arise from
aneuploidy, genome disorganization or abnormal DNA methylation. To map such patterns …
aneuploidy, genome disorganization or abnormal DNA methylation. To map such patterns …
Patient-specific data fusion defines prognostic cancer subtypes
Different data types can offer complementary perspectives on the same biological
phenomenon. In cancer studies, for example, data on copy number alterations indicate …
phenomenon. In cancer studies, for example, data on copy number alterations indicate …
Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review
A variety of genome-wide profiling techniques are available to investigate complementary
aspects of genome structure and function. Integrative analysis of heterogeneous data …
aspects of genome structure and function. Integrative analysis of heterogeneous data …
Double-blind, placebo-controlled, multicenter, randomized, Phase IIB neoadjuvant study of letrozole-lapatinib in postmenopausal hormone receptor–positive, human …
V Guarneri, DG Generali, A Frassoldati… - Journal of Clinical …, 2014 - ascopubs.org
Purpose This is a randomized, double-blind, placebo-controlled study aimed to evaluate the
clinical and biologic effects of letrozole plus lapatinib or placebo as neoadjuvant therapy in …
clinical and biologic effects of letrozole plus lapatinib or placebo as neoadjuvant therapy in …
Lessons from a decade of integrating cancer copy number alterations with gene expression profiles
Over the last decade, multiple functional genomic datasets studying chromosomal
aberrations and their downstream effects on gene expression have accumulated for several …
aberrations and their downstream effects on gene expression have accumulated for several …