Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

Whole-genome duplication (WGD) events have shaped the history of many evolutionary
lineages. One such duplication has been implicated in the evolution of teleost fishes, by far …

The automobile tire antioxidant N-(1, 3-dimethylbutyl)-N'-phenyl-p-phenylenediamine
(6PPD) and its quinone metabolite 6PPDQ have recently received much attention for their …

The RPE65 gene encodes the isomerase of the retinoid cycle, the enzymatic pathway that
underlies mammalian vision. Mutations in RPE65 disrupt the retinoid cycle and cause a …

Cone photoreceptors mediate our daytime vision and function under bright and rapidly-
changing light conditions. As their visual pigment is destroyed in the process of …

Müller glia function as retinal stem cells in adult zebrafish. In response to loss of retinal
neurons, Müller glia partially dedifferentiate, re-express neuroepithelial markers and re …

The chromophore of all known visual pigments consists of 11-cis-retinal (derived from either
vitamin A1 or A2) or a hydroxylated derivative, bound to a protein (opsin) via a Schiff base …

Considerable research on normal and diseased states within the retina has focused on
neurons. Recent research on glia throughout the central nervous system, including within …

Purpose: To describe new details of epiretinal cell proliferation in flat-mounted internal
limiting membrane specimens. Methods: One hundred nineteen internal limiting membrane …

Mutations in the cellular retinaldehyde–binding protein (CRALBP, encoded by RLBP1) can
lead to severe cone photoreceptor–mediated vision loss in patients. It is not known how …