Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily developing and was approved for the …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme
with the unique property to participate in both the citric acid cycle and the electron transport …

Ovarian cancer is a silent cancer which rate survival mainly relays in early stage detection.
The discovery of reliable ovarian cancer biomarkers plays a crucial role in the disease …

Metabolic reprogramming is associated with resistance to antiangiogenic therapy in cancer.
However, its molecular mechanisms have not been clearly elucidated. Here, we identify the …

Significance: Cancer cells are stabilized in an undifferentiated state similar to stem cells.
This leads to profound modifications of their metabolism, which further modifies their …

The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions
that are reprogramed and upregulated in cancer; these pathways are involved in supporting …

Advances in cell metabolism over the past few decades have demonstrated glutamine as an
essential nutrient for cancer cell survival and proliferation. Glutamine offers a remarkable …

Abstract 18F-FDG PET/CT has been used as an indicator of chemotherapy effects, but
cancer cells can remain even when no FDG uptake is detected, indicating the importance of …

Prostate cancer, as one of the most prevalent malignancies in males, exhibits an
approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events …