The emerging potential of Aptamers as therapeutic agents in infection and inflammation

M Stephens - Pharmacology & Therapeutics, 2022 - Elsevier
Refined from pools of random sequence oligonucleotides, nucleic acid aptamers have been
found to bind an almost limitless array of targets, including clinically-relevant proteins …

Relationship between pyroptosis-mediated inflammation and the pathogenesis of prostate disease

M Zhao, J Guo, QH Gao, H Wang, F Wang… - Frontiers in …, 2023 - frontiersin.org
The largest solid organ of the male genitalia, the prostate gland, is comprised of a variety of
cells such as prostate epithelial cells, smooth muscle cells, fibroblasts, and endothelial cells …

Ursolic acid alleviates chronic prostatitis via regulating NLRP3 inflammasome‐mediated Caspase‐1/GSDMD pyroptosis pathway

S Liu, B Guo, Q Gao, Y Deng, B Yan… - Phytotherapy …, 2024 - Wiley Online Library
Ursolic acid (UA) is a naturally occurring pentacyclic triterpenoid widely found in fruits and
vegetables. It has been reported that UA has anti‐inflammatory effects. However, its efficacy …

IL-1β-primed mesenchymal stromal cells exert enhanced therapeutic effects to alleviate Chronic Prostatitis/Chronic Pelvic Pain Syndrome through systemic immunity

H Liu, X Zhu, X Cao, A Chi, J Dai, Z Wang… - Stem Cell Research & …, 2021 - Springer
Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) seriously affects
patient health. Despite the elusiveness of innate therapeutic effects, mesenchymal stromal …

Investigating the multi-target therapeutic mechanism of Guihuang formula on Chronic Prostatitis

S Liu, F Zhao, Y Deng, Y Zeng, B Yan, J Guo… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Chronic prostatitis (CP) is a complex, intractable and
prevalent urological disorder in men with no effective treatment. Guihuang formula (GHF) is …

Do Marine Polysaccharides Carrageenans Modulate Non-apoptotic Regulated Cell Deaths?(a Review)

A Tkachenko, A Onishchenko, V Prokopiuk - Current Pharmacology …, 2023 - Springer
Purpose of Review A growing number of studies indicate that a network of regulated cell
death (RCD) pathways plays a vital role in tumorigenesis suggesting its targeting to be a …

The causative effect of CXCR7 on experimental autoimmune prostatitis injury and fibrosis

Y Zhang, R Feng, S Chen, Z Wang, C Huang… - International …, 2025 - Elsevier
Abstract Chronic prostatitis and Pelvic Pain syndrome (CP/CPPS) is an autoimmune
inflammatory disease characterized by pelvic or perineal pain and infiltration of inflammatory …

bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential …

J Yang, Y Tabuchi, R Katsuki, M Taki - International Journal of Molecular …, 2023 - mdpi.com
Monoclonal antibody therapies targeting immuno-modulatory targets such as checkpoint
proteins, chemokines, and cytokines have made significant impact in several areas …

Nucleic acids for potential treatment of rheumatoid arthritis

P Sun, J Su, X Wang, M Zhou, Y Zhao… - ACS Applied Bio …, 2022 - ACS Publications
Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease that
severely affects the life quality of patients. Current therapeutics in clinic mainly focus on …

Локальная цитокинотерапия в комплексном лечении хронического простатита

ИА Тюзиков, ЕА Греков, АВ Смирнов - Эффективная фармакотерапия, 2022 - elibrary.ru
С учетом современной концепции нейроиммуноэндокринологии, согласно которой в
организме на всех уровнях регуляции происходит тесное взаимодействие сигнальных …