Iron is an essential but potentially hazardous biometal. Mammalian cells require sufficient
amounts of iron to satisfy metabolic needs or to accomplish specialized functions. Iron is …

The neurodegenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD),
are age-related disorders characterized by the deposition of abnormal forms of specific …

Zinc oxide nanoparticles (ZnONPs) hold great promise for biomedical applications. Previous
studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on
physiology and homeostasis—understanding how cells and organisms regulate their iron …

Iron is an essential nutrient with limited bioavailability. When present in excess, iron poses a
threat to cells and tissues, and therefore iron homeostasis has to be tightly controlled. Iron's …

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are mammalian proteins that register
cytosolic iron concentrations and post-transcriptionally regulate expression of iron …

Ascorbate is a cofactor in numerous metabolic reactions. Humans cannot synthesize
ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone …

Oh what a difference a decade makes! In a landmark paper published in 1996, Feder and
colleagues identified the long-sought gene mutated in patients with classical hereditary …

Cellular iron homeostasis is accomplished by the coordinated regulated expression of the
transferrin receptor and ferritin, which mediate iron uptake and storage, respectively. The …