Type 1 diabetes (T1D) is an autoimmune disease that resulted from the severe destruction of
the insulin-producing β cells in the pancreases of individuals with a genetic predisposition …

N6-methyladenosine (m6A) methylation has been reported to play a role in type 2 diabetes
(T2D). However, the key component of m6A methylation has not been well explored in T2D …

We elucidated the effect of four known T1D-susceptibility associated single nucleotide
polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in …

Organ-specific autoimmune diseases, such as type 1 diabetes, are believed to result from T-
cell-mediated damage of the target tissue. The immune-mediated tissue injury, in turn, is …

Obesity and diabetes are a problem of modern medicine. Although the environmental factors
contributing to the development of these diseases are widely known, research into genetic …

Background Obesity and diabetes are a problem of modern medicine. Although the
environmental factors contributing to the development of these diseases are widely known …

The field of epigenetics broadly seeks to define heritable phenotypic modifications that occur
within cells without changes to the underlying DNA sequence. These modifications allow for …

Background Type 1 Diabetes (T1D) is a heterogenous autoimmune disorder, whereby the
immune system specifically targets and destroys the pancreatic beta cells, leading to little to …

Abstract Type 1 diabetes (T1D) results from progressive autoimmune-mediated destruction
of insulinproducing beta (β)-cells in pancreatic islets. The most effective biomarkers used to …

Type 1 diabetes is a chronic autoimmune disease, in which insulin secreting beta cells in the
pancreas are destroyed. The disease pathogenesis can be divided into an asymptomatic …