Hepatocellular carcinoma surveillance—Utilization, barriers and the impact of changing aetiology

DQ Huang, AG Singal, F Kanwal… - Nature Reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Surveillance for HCC is critical for early detection and treatment, but fewer than one-quarter …

Epidemiology and surveillance for hepatocellular carcinoma: New trends

AG Singal, P Lampertico, P Nahon - Journal of hepatology, 2020 - Elsevier
The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although
its incidence and mortality are rapidly rising in the United States and Europe. With the …

HCV eradication induced by direct-acting antiviral agents reduces the risk of hepatocellular carcinoma

GN Ioannou, PK Green, K Berry - Journal of hepatology, 2018 - Elsevier
Background & Aims It is unclear whether direct-acting antiviral (DAA) treatment-induced
sustained virologic response (SVR) reduces the risk of hepatocellular carcinoma (HCC) in …

Surveillance for hepatocellular carcinoma: current best practice and future direction

F Kanwal, AG Singal - Gastroenterology, 2019 - Elsevier
Hepatocellular cancer (HCC) is the fourth leading cause of cancer-related deaths worldwide
and the fastest growing cause of cancer deaths in the United States. The overall prognosis …

Increased risk for hepatocellular carcinoma persists up to 10 years after HCV eradication in patients with baseline cirrhosis or high FIB-4 scores

GN Ioannou, LA Beste, PK Green, AG Singal… - Gastroenterology, 2019 - Elsevier
Background & Aims It is unclear if hepatocellular carcinoma (HCC) risk declines over time
after hepatitis C virus (HCV) eradication. We analyzed changes in HCC annual incidence …

Use of hepatocellular carcinoma surveillance in patients with cirrhosis: a systematic review and meta‐analysis

E Wolf, NE Rich, JA Marrero, ND Parikh… - Hepatology, 2021 - Wiley Online Library
Background and Aims Hepatocellular carcinoma (HCC) surveillance is associated with early
tumor detection and improved survival; however, it is often underused in clinical practice. We …

Hepatocellular carcinoma in the absence of cirrhosis in United States veterans is associated with nonalcoholic fatty liver disease

S Mittal, HB El-Serag, YH Sada, F Kanwal… - Clinical …, 2016 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) can develop in individuals without
cirrhosis. We investigated risk factors for development of HCC in the absence of cirrhosis in …

[PDF][PDF] Long‐term risk of hepatocellular carcinoma in HCV patients treated with direct acting antiviral agents

F Kanwal, JR Kramer, SM Asch, Y Cao, L Li… - …, 2020 - Wiley Online Library
Sustained virologic response (SVR) after direct acting antiviral agents (DAAs) holds promise
for reducing hepatocellular cancer (HCC). DAAs have recently been available long enough …

Hepatocellular carcinoma from epidemiology to prevention: translating knowledge into practice

AG Singal, HB El-Serag - Clinical gastroenterology and hepatology, 2015 - Elsevier
The epidemiology of hepatocellular carcinoma (HCC) is characterized by dynamic temporal
trends, several major established (ie, HCV, HBV, alcohol) and emerging (ie, diabetes …

Trends in burden of cirrhosis and hepatocellular carcinoma by underlying liver disease in US veterans, 2001–2013

LA Beste, SL Leipertz, PK Green, JA Dominitz, D Ross… - Gastroenterology, 2015 - Elsevier
Background & Aims Cirrhosis and hepatocellular carcinoma (HCC) are predicted to increase
in the United States but the accuracy of prior forecasts and the contributions from various …