In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

Medical image processing and analysis (also known as Radiomics) is a rapidly growing
discipline that maps digital medical images into quantitative data, with the end goal of …

Human epidermal growth factor receptor 2 (HER2) regulates cell mitosis, proliferation, and
apoptosis. Trastuzumab is a HER2-targeted monoclonal antibody (mAB), which can prolong …

Radiographic imaging is routinely used to evaluate treatment response in solid tumors.
Current imaging response metrics do not reliably predict the underlying biological response …

In the past decade, the field of medical image analysis has grown exponentially, with an
increased number of pattern recognition tools and an increase in data set sizes. These …

Purpose: To identify MRI-based radiomics as prognostic factors in patients with advanced
nasopharyngeal carcinoma (NPC). Experimental Design: One-hundred and eighteen …

Intratumor heterogeneity (ITH) profoundly affects therapeutic responses and clinical
outcomes. However, the widespread methods for assessing ITH based on genomic …

Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Purpose Refinement of radiomic results and methodologies is required to ensure
progression of the field. In this work, we establish a set of safeguards designed to improve …

The extent of tumor heterogeneity is an emerging theme that researchers are only beginning
to understand. How genetic and epigenetic heterogeneity affects tumor evolution and …