Systemic sclerosis (SSc) is a prototypical inflammatory fibrotic disease involving
inflammation, vascular abnormalities and fibrosis that primarily affect the skin and lungs. The …

The mechanistic target of rapamycin (mTOR) is a master regulator of the inflammatory
response in immune and non-immune cells. In immune cells mTOR regulates metabolism to …

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular
abnormalities, immunological alterations and fibrosis of the skin and internal organs. The …

In recent years, epigenetic modifications have been widely researched. As humans age,
environmental and genetic factors may drive inflammation and immune responses by …

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …

Autoimmune diseases (AID) have emerged as prominent contributors to disability and
mortality worldwide, characterized by intricate pathogenic mechanisms involving genetic …

Systemic sclerosis is a rare acquired systemic disease characterised by a complex
pathogenesis and multi organ involvement. Every year the scientific world contributes to …

Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous,
multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon …

Systemic sclerosis (SSc, scleroderma) is a severe autoimmune connective tissue disease
characterized by widespread peripheral microvasculopathy, and progressive cutaneous and …