Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques,
neurofibrillary tangles, and neuronal loss, accompanied by neuroinflammation …

Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …

Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

Cutaneous wounds are among the most common soft tissue injuries and are particularly
hard to heal in aging. Caloric restriction (CR) is well documented to extend longevity; …

Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …

Background The association between long-term metformin use and low vitamin B12 levels
has been proven. However, the prevalence estimates of metformin-induced vitamin B12 …

Parkinson's disease (PD) is a serious neurodegenerative disorder marked by significant
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …

Spinal cord injury (SCI) is a severe neurological disease with few efficacious drugs.
Autophagy is a cellular process to confront with stress after SCI and considered to be a …