Scorpion venom components as potential candidates for drug development

E Ortiz, GB Gurrola, EF Schwartz, LD Possani - Toxicon, 2015 - Elsevier
Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …

Scorpion venom components that affect ion-channels function

V Quintero-Hernández, JM Jiménez-Vargas… - Toxicon, 2013 - Elsevier
The number and types of venom components that affect ion-channel function are reviewed.
These are the most important venom components responsible for human intoxication …

Scorpions from Mexico: From species diversity to venom complexity

CE Santibáñez-López, OF Francke, C Ureta… - Toxins, 2015 - mdpi.com
Scorpions are among the oldest terrestrial arthropods, which are distributed worldwide,
except for Antarctica and some Pacific islands. Scorpion envenomation represents a public …

[HTML][HTML] Strategies for heterologous expression, synthesis, and purification of animal venom toxins

E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

Diversity of peptide toxins from stinging ant venoms

SR Aili, A Touchard, P Escoubas, MP Padula, J Orivel… - Toxicon, 2014 - Elsevier
Abstract Ants (Hymenoptera: Formicidae) represent a taxonomically diverse group of
arthropods comprising nearly 13,000 extant species. Sixteen ant subfamilies have …

Centipede venom: recent discoveries and current state of knowledge

EAB Undheim, BG Fry, GF King - Toxins, 2015 - mdpi.com
Centipedes are among the oldest extant venomous predators on the planet. Armed with a
pair of modified, venom-bearing limbs, they are an important group of predatory arthropods …

Diversity of potassium channel ligands: focus on scorpion toxins

AI Kuzmenkov, EV Grishin, AA Vassilevski - Biochemistry (Moscow), 2015 - Springer
Potassium (K+) channels are a widespread superfamily of integral membrane proteins that
mediate selective transport of K+ ions through the cell membrane. They have been found in …

Glioblastoma multiforme targeted therapy: The Chlorotoxin story

O Cohen-Inbar, M Zaaroor - Journal of Clinical Neuroscience, 2016 - Elsevier
Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm
having a mean survival of< 24 months. Scorpion toxins are considered promising cancer …

Profiling the resting venom gland of the scorpion Tityus stigmurus through a transcriptomic survey

DD Almeida, KC Scortecci, LS Kobashi, LF Agnez-Lima… - BMC genomics, 2012 - Springer
Abstract Background The scorpion Tityus stigmurus is widely distributed in Northeastern
Brazil and known to cause severe human envenoming, inducing pain, hyposthesia, edema …

Global Transcriptome Analysis of the Scorpion Centruroides noxius: New Toxin Families and Evolutionary Insights from an Ancestral Scorpion Species

M Rendón-Anaya, L Delaye, LD Possani… - 2012 - journals.plos.org
Scorpion venoms have been studied for decades, leading to the identification of hundreds of
different toxins with medical and pharmacological implications. However, little emphasis has …