Sex and gender in asthma

NU Chowdhury, VP Guntur… - European …, 2021 - Eur Respiratory Soc
Asthma is a heterogenous disease, and its prevalence and severity are different in males
versus females through various ages. As children, boys have an increased prevalence of …

[HTML][HTML] Epidemiology of asthma in children and adults

SC Dharmage, JL Perret, A Custovic - Frontiers in pediatrics, 2019 - frontiersin.org
Asthma is a globally significant non-communicable disease with major public health
consequences for both children and adults, including high morbidity, and mortality in severe …

After asthma: redefining airways diseases

ID Pavord, R Beasley, A Agusti, GP Anderson, E Bel… - The Lancet, 2018 - thelancet.com
Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Phenotypes and endotypes of adult asthma: moving toward precision medicine

R Kaur, G Chupp - Journal of Allergy and Clinical Immunology, 2019 - Elsevier
Asthma is a chronic inflammatory disease of the airways that is challenging to dissect into
subgroups because of the heterogeneity present across the spectrum of the disease. Efforts …

Severe and difficult-to-treat asthma in adults

E Israel, HK Reddel - New England Journal of Medicine, 2017 - Mass Medical Soc
Severe and Difficult-to-Treat Asthma in Adults | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double …

GL Chupp, ES Bradford, FC Albers… - The Lancet …, 2017 - thelancet.com
Background Mepolizumab, an anti-interleukin-5 monoclonal antibody approved as add-on
therapy to standard of care for patients with severe eosinophilic asthma, has been shown in …

Neutrophilic inflammation in asthma and association with disease severity

A Ray, JK Kolls - Trends in immunology, 2017 - cell.com
Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of
eosinophils and mast cells, and their role in the disease have long been recognized …

Allergic endotypes and phenotypes of asthma

N Akar-Ghibril, T Casale, A Custovic… - The Journal of Allergy …, 2020 - Elsevier
Allergic asthma is defined as asthma associated with sensitization to aeroallergens, which
leads to asthma symptoms and airway inflammation. Allergic asthma is the most common …

Type 2 inflammation in asthma—present in most, absent in many

JV Fahy - Nature Reviews Immunology, 2015 - nature.com
Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …

Commonality of the IL-4/IL-13 pathway in atopic diseases

NA Gandhi, G Pirozzi, NMH Graham - Expert review of clinical …, 2017 - Taylor & Francis
Introduction: Allergy results from an aberrant Type 2 inflammatory response, triggered by a
wide range of environmental antigens (allergens) that lead to various immune responses …