This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Mechanical forces are fundamental in cardiovascular biology, and deciphering the
mechanisms by which they act remains a testing frontier in cardiovascular research. Here …

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …

The anatomy and physiology of the microcirculation in human skin are complex. Normal
cutaneous microcirculation is organized in two parallel plexuses with capillary loops …

Bacteria represent one of the most evolutionarily successful groups of organisms to inhabit
Earth. Their world is awash with mechanical cues, probably the most ancient form of which …

Functional neuroimaging, such as fMRI, is based on coupling neuronal activity and
accompanying changes in cerebral blood flow (CBF) and metabolism. However, the …

Recent studies have suggested that certain (−)-epicatechin-containing foods have a blood
pressure-lowering capacity. The mechanisms underlying (−)-epicatechin action may help …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Tissue organoids hold enormous potential as tools for a variety of applications, including
disease modeling and drug screening. To effectively mimic the native tissue environment, it …