Tissue repair and regeneration after damage is not completely understood, and current
therapies to support this process are limited. The wound healing process is associated with …

Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Background Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or
trauma and usually leads to esthetic disfiguration and functionary impairment for patients …

Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large
number of patients still lack effective countermeasures. Recently, the reprogramming of …

Liver fibrosis is a chronic liver disease with the presence of progressive wound healing
response caused by liver injury. Currently, there are no approved therapies for liver fibrosis …

Increases in adipocyte volume and tissue mass due to obesity can result in inflammation,
further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like …

Around 40% of the population will suffer at some point in their life a disease involving tissue
loss or an inflammatory or autoimmune process that cannot be satisfactorily controlled with …

Liver disease is a leading cause of mortality and morbidity that is rising globally. Liver
dysfunctions are classified into acute and chronic diseases. Various insults, including viral …

Extracellular vesicles (EVs) have shown great potential in disease diagnosis and treatment;
however, their clinical applications remain challenging due to their unsatisfactory long-term …

Background Hair follicle-derived mesenchymal stem cell (HF-MSC)-based therapies protect
against acute pancreatitis (AP). However, accumulating evidence suggests that MSC-based …