Molecular and cellular heterogeneity in rheumatoid arthritis: mechanisms and clinical implications

J Zhao, S Guo, SJ Schrodi, D He - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis is an autoimmune disease that exhibits significant clinical
heterogeneity. There are various treatments for rheumatoid arthritis, including disease …

Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis

AK Rana, Y Li, Q Dang, F Yang - International immunopharmacology, 2018 - Elsevier
Rheumatoid arthritis (RA) is a chronic systemic, autoimmune and inflammatory disease
represented as synovitis, pannus formation, adjacent bone erosions, and joint destruction …

T cell migration in rheumatoid arthritis

M Mellado, L Martínez-Muñoz, G Cascio… - Frontiers in …, 2015 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
in joints, associated with synovial hyperplasia and with bone and cartilage destruction …

Emerging role of long noncoding RNAs in autoimmune diseases

GC Wu, HF Pan, RX Leng, DG Wang, XP Li, XM Li… - Autoimmunity …, 2015 - Elsevier
Long noncoding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of
noncoding RNA. Emerging evidence has revealed that lncRNAs play a key role in the …

Th17 cells in autoimmune and infectious diseases

JF Zambrano-Zaragoza… - International journal …, 2014 - Wiley Online Library
The view of CD4 T‐cell‐mediated immunity as a balance between distinct lineages of Th1
and Th2 cells has changed dramatically. Identification of the IL‐17 family of cytokines and of …

[HTML][HTML] Dendritic cells and CCR7 expression: an important factor for autoimmune diseases, chronic inflammation, and cancer

EP Brandum, AS Jørgensen, MM Rosenkilde… - International journal of …, 2021 - mdpi.com
Chemotactic cytokines—chemokines—control immune cell migration in the process of
initiation and resolution of inflammatory conditions as part of the body's defense system …

Dendritic cells, T cells and their interaction in rheumatoid arthritis

P Wehr, H Purvis, SC Law… - Clinical & Experimental …, 2019 - academic.oup.com
Dendritic cells (DCs) are the key professional antigen-presenting cells which bridge innate
and adaptive immune responses, inducing the priming and differentiation of naive to effector …

The T helper type 17/regulatory T cell paradigm in pregnancy

AS Figueiredo, A Schumacher - Immunology, 2016 - Wiley Online Library
Summary T helper type 17 (Th17) and regulatory T (Treg) cells are active players in the
establishment of tolerance and defence. These attributes of the immune system enmesh to …

[PDF][PDF] One year in review: the pathogenesis of rheumatoid arthritis

V Picerno, F Ferro, A Adinolfi, E Valentini… - Clin Exp …, 2015 - clinexprheumatol.org
The pathogenesis of rheumatoid arthritis (RA) is a complex scenario that, to date, is not fully
elucidated. However, scientific progress has enabled us to understand several mechanisms …

Migration and homeostasis of regulatory T cells in rheumatoid arthritis

K Kotschenreuther, S Yan, DM Kofler - Frontiers in Immunology, 2022 - frontiersin.org
Regulatory T (Treg) cells are garnering increased attention in research related to
autoimmune diseases, including rheumatoid arthritis (RA). They play an essential role in the …