Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and …

R Ahmad, M Riaz, A Khan, A Aljamea… - Phytotherapy …, 2021 - Wiley Online Library
Reishi owes an exceptional value in nutritional, cosmeceutical, and medical treatments;
however, none of the studies has provided its future‐driven critical assessment. This study …

Therapeutic potential and nutritional significance of Ganoderma lucidum–a comprehensive review from 2010 to 2022

MS Swallah, P Bondzie-Quaye, Y Wu… - Food & function, 2023 - pubs.rsc.org
With a long history in traditional Asian medicine, Ganoderma lucidum (G. lucidum) is a
mushroom species suggested to improve health and extend life. Its medicinal reputation has …

Prediction of drug efficacy from transcriptional profiles with deep learning

J Zhu, J Wang, X Wang, M Gao, B Guo, M Gao… - Nature …, 2021 - nature.com
Drug discovery focused on target proteins has been a successful strategy, but many
diseases and biological processes lack obvious targets to enable such approaches. Here, to …

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

X Geng, A Ma, J He, L Wang, Y Jia, G Shao… - Acta Pharmacologica …, 2020 - nature.com
Renal fibrosis is considered as the pathway of almost all kinds of chronic kidney diseases
(CKD) to the end stage of renal diseases (ESRD). Ganoderic acid (GA) is a group of …

Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats

J Sun, J Fan, T Li, X Yan, Y Jiang - Journal of Agricultural and …, 2022 - ACS Publications
Our previous study showed that nuciferine (NF) attenuated non-alcoholic fatty liver disease
(NAFLD), which is attributed to a high-fat diet (HFD) through reinforcing intestinal barrier …

Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action

MF Ahmad, FA Ahmad, M Zeyaullah, AA Alsayegh… - Nutrients, 2023 - mdpi.com
Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible
and traditional medicinal mushroom for thousands of years in Asian countries. It is currently …

Polysaccharide peptides from Ganoderma lucidum ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed rats

XC Lv, WL Guo, L Li, XD Yu, B Liu - Journal of Functional Foods, 2019 - Elsevier
This study aimed to investigate the effects of polysaccharide peptides from Ganoderma
lucidum (GLPP) on hyperlipidaemia and gut microbiota dysbiosis in high-fat diet (HFD) …

A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice

W Shao, C Xiao, T Yong, Y Zhang, H Hu, T Xie… - International Journal of …, 2022 - Elsevier
In this study, we reported a thermal stable and non-toxic heteropolysaccharide F31, which
decreased the blood glucose of diabetic mice (21.75 mmol/L) induced by high-fat diet (HFD) …

Polysaccharides: the potential prebiotics for metabolic associated fatty liver disease (MAFLD)

Q Guo, Y Li, X Dai, B Wang, J Zhang, H Cao - Nutrients, 2023 - mdpi.com
Metabolic (dysfunction) associated fatty liver disease (MAFLD) is recognized as the most
prevalent chronic liver disease globally. However, its pathogenesis remains incompletely …

Apple polyphenol extract improves high-fat diet-induced hepatic steatosis by regulating bile acid synthesis and gut microbiota in C57BL/6 male mice

D Li, Y Cui, X Wang, F Liu, X Li - Journal of agricultural and food …, 2021 - ACS Publications
Our previous study showed that apple polyphenol extract (APE) ameliorated high-fat diet-
induced hepatic steatosis in C57BL/6 mice by targeting the LKB1/AMPK pathway; to …