Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …
Mirabegron, dependent on β3-adrenergic receptor, alleviates mercuric chloride-induced kidney injury by reversing the impact on the inflammatory network, M1/M2 …
MM Kamal, HS El-Abhar, DM Abdallah… - International …, 2024 - Elsevier
The β3-adrenergic receptor (β3-AR) agonism mirabegron is used to treat overactive urinary
bladder syndrome; however, its role against acute kidney injury (AKI) is not unveiled, hence …
bladder syndrome; however, its role against acute kidney injury (AKI) is not unveiled, hence …
Farnesol Inhibits PI3 Kinase Signaling and Inflammatory Gene Expression in Primary Human Renal Epithelial Cells
A Müller, M Lozoya, X Chen, V Weissig, M Nourbakhsh - Biomedicines, 2023 - mdpi.com
Chronic inflammation and elevated cytokine levels are closely associated with the
progression of chronic kidney disease (CKD), which is responsible for the manifestation of …
progression of chronic kidney disease (CKD), which is responsible for the manifestation of …
HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway
G Yang, F Su, B Han, H Su, C Guo, S Yu… - Biochemical …, 2024 - Elsevier
Despite the exact biological role of HNF1 homolog A (HNF1A) in the regulatory mechanism
of glioblastoma (GBM), the molecular mechanism, especially the downstream regulation as …
of glioblastoma (GBM), the molecular mechanism, especially the downstream regulation as …