Vascular calcification is associated with atherosclerosis, chronic kidney disease, and
diabetes, and results from processes resembling endochondral or intramembranous …

Mitochondria are crucial bioenergetics powerhouses and biosynthetic hubs within cells,
which can generate and sequester toxic reactive oxygen species (ROS) in response to …

The autophagy pathway is a key regulator of cellular metabolism and homeostasis, and
plays a critical role in maintaining normal vascular cell function. It is well recognised that …

Arterial media calcification is related to mitochondrial dysfunction. Protective mitophagy
delays the progression of vascular calcification. We previously reported that lactate …

Recent studies have shown that short-chain fatty acids (SCFAs), primarily acetate,
propionate and butyrate, play a crucial role in the pathogenesis of cardiovascular disease …

Vascular calcification is a complex pathological process occurring in patients with
atherosclerosis, type 2 diabetes, and chronic kidney disease. The extracellular matrix, via …

Extracellular matrix (ECM) exerts a series of biological functions and contributes to almost
30% of the osteogenic process. Periostin is a secreted protein that can alter ECM …

Bone morphogenetic protein signaling has long been established as a crucial pathway
during embryonic development. In recent years, our knowledge of the function of bone …

Objective—We hypothesized that ob/ob mice develop expansive vascular remodeling
associated with calcification. Approach and Results—We quantified and investigated …

Early vascular ageing (EVA) is a pathological phenomenon whereby the vascular system
ages more quickly than chronological age. This underpins many cardiovascular diseases …