Beyond polydimethylsiloxane: alternative materials for fabrication of organ-on-a-chip devices and microphysiological systems

SB Campbell, Q Wu, J Yazbeck, C Liu… - ACS biomaterials …, 2020 - ACS Publications
Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …

Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices

AE Ongaro, Z Ndlovu, E Sollier, C Otieno, P Ondoa… - Lab on a Chip, 2022 - pubs.rsc.org
Single-use, disposable, point-of-care diagnostic devices carry great promise for global
health, including meeting urgent needs for testing and diagnosis in places with limited …

Advances in organ-on-a-chip materials and devices

BK Nahak, A Mishra, S Preetam… - ACS applied bio …, 2022 - ACS Publications
The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical
to clinical translational precision. The current trends in the in vitro modeling is to reduce the …

Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization

S Liu, S Kumari, H He, P Mishra, BN Singh… - Biosensors and …, 2023 - Elsevier
As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …

Microfluidic skin‐on‐a‐chip models: Toward biomimetic artificial skin

E Sutterby, P Thurgood, S Baratchi, K Khoshmanesh… - Small, 2020 - Wiley Online Library
The role of skin in the human body is indispensable, serving as a barrier, moderating
homeostatic balance, and representing a pronounced endpoint for cosmetics and …

[HTML][HTML] Bio-functionalization of microfluidic platforms made of thermoplastic materials: A review

A Shakeri, NA Jarad, S Khan, TF Didar - Analytica Chimica Acta, 2022 - Elsevier
As a result of their favorable physical and chemical characteristics, thermoplastics have
garnered significant interest in the area of microfluidics. The moldable nature of these …

Translational roadmap for the organs-on-a-chip industry toward broad adoption

V Allwardt, AJ Ainscough, P Viswanathan, SD Sherrod… - Bioengineering, 2020 - mdpi.com
Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to
change the efficiency, effectiveness, and costs of the drug discovery process; to advance …

Biomedical application of functional materials in organ-on-a-chip

C Ding, X Chen, Q Kang, X Yan - Frontiers in bioengineering and …, 2020 - frontiersin.org
The organ-on-a-chip (OOC) technology has been utilized in a lot of biomedical fields such
as fundamental physiological and pharmacological researches. Various materials have …

Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges

P Zarrintaj, MR Saeb, FJ Stadler, MK Yazdi… - Advanced …, 2022 - Wiley Online Library
New emerging technologies, remarkably miniaturized 3D organ models and microfluidics,
enable simulation of the real in vitro microenvironment ex vivo more closely. There are many …

[HTML][HTML] Tumor-on-a-chip models combined with mini-tissues or organoids for engineering tumor tissues

H Hwangbo, SJ Chae, W Kim, S Jo, GH Kim - Theranostics, 2024 - ncbi.nlm.nih.gov
The integration of tumor-on-a-chip technology with mini-tissues or organoids has emerged
as a powerful approach in cancer research and drug development. This review provides an …