Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Ageing is the largest risk factor for many chronic diseases. Studies of heterochronic
parabiosis, substantiated by blood exchange and old plasma dilution, show that old-age …

An aged circulatory environment can activate microglia, reduce neural precursor cell activity
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …

Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose
regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient …

Aging involves a decline in neural function that contributes to cognitive impairment and
disease. However, the mechanisms underlying the transition from a young-and-healthy to …

Heterochronic parabiosis rejuvenates the performance of old tissue stem cells at some
expense to the young, but whether this is through shared circulation or shared organs is …

Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB),
protecting the brain from pathogens and restricting access of circulatory factors. Yet …

Ageing is associated with the functional decline of all tissues and a striking increase in many
diseases. Although ageing has long been considered a one-way street, strategies to delay …

Aging causes many changes in the human body, and is a high risk for various diseases.
Dementia, a common age-related disease, is a clinical disorder triggered by …