Urgency and necessity of Epstein-Barr virus prophylactic vaccines

L Zhong, C Krummenacher, W Zhang, J Hong, Q Feng… - npj Vaccines, 2022 - nature.com
Abstract Epstein-Barr virus (EBV), a γ-herpesvirus, is the first identified oncogenic virus,
which establishes permanent infection in humans. EBV causes infectious mononucleosis …

[HTML][HTML] Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

X Shen, D Pan, Q Gong, Z Gu, K Luo - Bioactive Materials, 2024 - Elsevier
Effective tumor treatment depends on optimizing drug penetration and accumulation in
tumor tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key …

Lymph node targeted multi-epitope subunit vaccine promotes effective immunity to EBV in HLA-expressing mice

V Dasari, LK McNeil, K Beckett, M Solomon… - Nature …, 2023 - nature.com
The recent emergence of a causal link between Epstein-Barr virus (EBV) and multiple
sclerosis has generated considerable interest in the development of an effective vaccine …

[HTML][HTML] Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV

CW Chao, KR Sprouse, MC Miranda, NJ Catanzaro… - Cell Reports, 2024 - cell.com
Middle East respiratory syndrome coronavirus (MERS-CoV) is a betacoronavirus that
causes severe respiratory illness in humans. There are no licensed vaccines against MERS …

Virological markers in Epstein–Barr virus-associated diseases

J Lupo, A Truffot, J Andreani, M Habib, O Epaulard… - Viruses, 2023 - mdpi.com
Epstein–Barr virus (EBV) is an oncogenic virus infecting more than 95% of the world's
population. After primary infection—responsible for infectious mononucleosis in young …

Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents

L Zhong, W Zhang, C Krummenacher, Y Chen… - Trends in …, 2023 - cell.com
Herpesviruses are among the most successful viruses found in human populations. They
establish lifelong latent infections, which are punctuated by recurrent reactivations. The entry …

Lessons learned from immunological characterization of nanomaterials at the Nanotechnology Characterization Laboratory

MA Dobrovolskaia - Frontiers in Immunology, 2022 - frontiersin.org
Nanotechnology carriers have become common in pharmaceutical products because of
their benefits to drug delivery, including reduced toxicities and improved efficacy of active …

Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection

J Hong, L Zhong, L Liu, Q Wu, W Zhang, K Chen… - Cell Reports …, 2023 - cell.com
Epstein-Barr virus (EBV) is closely associated with cancer, multiple sclerosis, and post-acute
coronavirus disease 2019 (COVID-19) sequelae. There are currently no approved …

A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge

KR Edwards, H Malhi, K Schmidt, AR Davis, LJ Homad… - npj Vaccines, 2024 - nature.com
Epstein-Barr virus (EBV) is associated with several malignancies, neurodegenerative
disorders and is the causative agent of infectious mononucleosis. A vaccine that prevents …

De Novo Design of Polyhedral Protein Assemblies: Before and After the AI Revolution

BB Mallik, J Stanislaw, TM Alawathurage… - …, 2023 - Wiley Online Library
Self‐assembling polyhedral protein biomaterials have gained attention as engineering
targets owing to their naturally evolved sophisticated functions, ranging from protecting …