Overlapping brain circuits for homeostatic and hedonic feeding
Central regulation of food intake is a key mechanism contributing to energy homeostasis.
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …
Many neural circuits that are thought to orchestrate feeding behavior overlap with the brain's …
The physiological control of eating: signals, neurons, and networks
AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
[HTML][HTML] A neural circuit for gut-induced reward
The gut is now recognized as a major regulator of motivational and emotional states.
However, the relevant gut-brain neuronal circuitry remains unknown. We show that optical …
However, the relevant gut-brain neuronal circuitry remains unknown. We show that optical …
Whole-brain mapping of direct inputs to midbrain dopamine neurons
M Watabe-Uchida, L Zhu, SK Ogawa, A Vamanrao… - Neuron, 2012 - cell.com
Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and
substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we …
substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we …
Chronic pain and chronic stress: two sides of the same coin?
CG Abdallah, P Geha - Chronic Stress, 2017 - journals.sagepub.com
Pain and stress share significant conceptual and physiological overlaps. Both phenomena
challenge the body's homeostasis and necessitate decision-making to help animals adapt to …
challenge the body's homeostasis and necessitate decision-making to help animals adapt to …
Dopamine in motivational control: rewarding, aversive, and alerting
ES Bromberg-Martin, M Matsumoto, O Hikosaka - Neuron, 2010 - cell.com
Midbrain dopamine neurons are well known for their strong responses to rewards and their
critical role in positive motivation. It has become increasingly clear, however, that dopamine …
critical role in positive motivation. It has become increasingly clear, however, that dopamine …
Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit
Pain decreases the activity of many ventral tegmental area (VTA) dopamine (DA) neurons,
yet the underlying neural circuitry connecting nociception and the DA system is not …
yet the underlying neural circuitry connecting nociception and the DA system is not …
Divergent neural pathways emanating from the lateral parabrachial nucleus mediate distinct components of the pain response
The lateral parabrachial nucleus (lPBN) is a major target of spinal projection neurons
conveying nociceptive input into supraspinal structures. However, the functional role of …
conveying nociceptive input into supraspinal structures. However, the functional role of …
Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry
E Navratilova, JY Xie, A Okun, C Qu… - Proceedings of the …, 2012 - National Acad Sciences
Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that
blockade of afferent input from the injury with local anesthetic elicits conditioned place …
blockade of afferent input from the injury with local anesthetic elicits conditioned place …
From belly to brain: targeting the ghrelin receptor in appetite and food intake regulation
Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and
subsequent food intake. The ghrelinergic system has therefore received considerable …
subsequent food intake. The ghrelinergic system has therefore received considerable …