Role of transglutaminase 2 in cell death, survival, and fibrosis

H Tatsukawa, K Hitomi - Cells, 2021 - mdpi.com
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …

The role of tissue transglutaminase in cancer cell initiation, survival and progression

C Tabolacci, A De Martino, C Mischiati, G Feriotto… - Medical …, 2019 - mdpi.com
Tissue transglutaminase (transglutaminase type 2; TG2) is the most ubiquitously expressed
member of the transglutaminase family (EC 2.3. 2.13) that catalyzes specific post …

ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL‑8/Notch signaling cascade

V Ciccone, E Terzuoli, E Ristori… - International …, 2022 - spandidos-publications.com
ALDH1A1 is a cytosolic enzyme upregulated in tumor cells, involved in detoxifying cells from
reactive aldehydes and in acquiring resistance to chemotherapeutic drugs. Its expression …

Structure-activity relationships of N-terminal variants of peptidomimetic tissue transglutaminase inhibitors

NMR McNeil, EWJ Gates, N Firoozi, NJ Cundy… - European journal of …, 2022 - Elsevier
Tissue transglutaminase (TG2) is a multifunctional protein that catalyses protein crosslinking
in the extracellular matrix, and functions as an intracellular G-protein. While both activities …

Quantitative proteomics and in-cell cross-linking reveal cellular reorganisation during early neuronal differentiation of SH-SY5Y cells

M Barth, A Toto Nienguesso… - Communications …, 2022 - nature.com
The neuroblastoma cell line SH-SY5Y is commonly employed to study neuronal function
and disease. This includes cells grown under standard conditions or differentiated to neuron …

Transglutaminase 2 associated with PI3K and PTEN in a membrane-bound signalosome platform blunts cell death

K Jambrovics, P Botó, A Pap, Z Sarang… - Cell Death & …, 2023 - nature.com
Abstract Atypically expressed transglutaminase 2 (TG2) has been identified as a poor
prognostic factor in a variety of cancers. In this study, we evaluated the contribution of TG2 to …

Metabolic characterisation of transglutaminase 2 inhibitor effects in breast cancer cell lines

M Gallo, E Ferrari, A Terrazzan, F Brugnoli… - The FEBS …, 2023 - Wiley Online Library
Transglutaminase 2 (TG2), which mediates post‐translational modifications of multiple
intracellular enzymes, is involved in the pathogenesis and progression of cancer. We used …

[HTML][HTML] Dysregulation of Transglutaminase type 2 through GATA3 defines aggressiveness and Doxorubicin sensitivity in breast cancer

G Aguiari, F Crudele, C Taccioli, L Minotti… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Dysregulation of Transglutaminase type 2 through GATA3 defines aggressiveness and
Doxorubicin sensitivity in breast cancer - PMC Back to Top Skip to main content NIH NLM Logo …

Overexpression of TG2 enhances the differentiation of ectomesenchymal stem cells into neuron‑like cells and promotes functional recovery in adult rats following …

W Shi, Y Que, D Lv, S Bi, Z Xu… - Molecular …, 2019 - spandidos-publications.com
Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the
cranial neural crest. These cells are capable of self‑renewal and have the potential for …

[HTML][HTML] Neutrophil elastase-mediated proteolysis of the tumor suppressor p200 CUX1 promotes cell proliferation and inhibits cell differentiation in APL

L Yu, L Zhong, L Xiong, W Dan, J Li, J Ye, P Wan… - Life sciences, 2020 - Elsevier
Aims Neutrophil elastase (NE) is a critical proteolytic enzyme that is involved in cancer. We
previously reported high NE expression in peripheral blood neutrophils from acute …