Pervasive transcription occurs in the human genome to generate thousands of RNA
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …

Targeted genome editing has become a powerful genetic tool for studying gene function or
for modifying genomes by correcting defective genes or introducing genes. A variety of …

The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired
stems and a core of highly conserved, non-complementary nucleotides essential for …

Minimal hammerhead ribozymes have been characterized extensively by static and time-
resolved crystallography as well as numerous biochemical analyses, leading to mutually …

The hammerhead ribozyme (HHRz) is a small, naturally occurring ribozyme that site-
specifically cleaves RNA and has long been considered a potentially useful tool for gene …

We have solved the crystal structure of an all-RNA hammerhead ribozyme having a single
2′-O-methyl cytosine incorporated at the active site to prevent cleavage. The conditions …

Background With continuing identification of novel structured noncoding RNAs, there is an
increasing need to create schematic diagrams showing the consensus features of these …

Ligand-specific molecular switches composed of RNA were created by coupling preexisting
catalytic and receptor domains via structural bridges. Binding of ligand to the receptor …

An RNA polymerase ribozyme that was obtained by directed evolution can propagate a
functional RNA through repeated rounds of replication and selection, thereby enabling …

An updated, practical guide to bioinorganic chemistry Bioinorganic Chemistry: A Short
Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry …