Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue
damage not only induces inflammation in general, it also determines the type and …

Intestinal fibrosis is one of the most threatening complications of Crohn's disease. It occurs in
more than a third of patients with this condition, is associated with increased morbidity and …

Chronic rhinosinusitis (CRS), a common clinical condition characterized by persistent
mucosal inflammation and tissue remodeling, has a complex pathogenesis that is intricately …

Intestinal fibrosis is an excessive proliferation of myofibroblasts and deposition of collagen, a
condition frequently seen in Crohn's disease (CD). The mechanism underlying myofibroblast …

Intestinal fibrosis associated stricture is a common complication of inflammatory bowel
disease usually requiring endoscopic or surgical intervention. Effective anti-fibrotic agents …

The focal adhesion protein, Hic-5 plays a key role in promoting extracellular matrix
deposition and remodeling by cancer associated fibroblasts within the tumor stroma to …

Inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC)
seriously affects the quality of life for patients. The pathogenesis of IBD contains the …

Summary Dysregulated interleukin-17 (IL-17) expression and its downstream signaling is
strongly linked to inflammatory bowel diseases (IBDs). However, the molecular mechanisms …

Sepsis is defined as dysregulated host response caused by systemic infection, leading to
organ failure. It is a life-threatening condition, often requiring admission to an intensive care …

Inflammatory bowel disease (IBD), which include Crohn's disease (CD) and ulcerative colitis
(UC), exhibits a complex multifactorial pathogenesis involving genetic susceptibility …